Tim Allen
Dave Douglas

Kristin Davis
Rebecca Douglas

Danny Glover
Ken Hollister

Spencer Breslin
Josh Douglas

Robert Downey Jr.
Dr. Kozak

Zena Grey
Carly Douglas

Joshua Leonard
Justin Forrester

Jane Curtin
Judge Claire Whittaker

Annabelle Gurwitch
Justin Forrester's Attorney

Jarrad Paul
Larry

Bess Wohl
Dr. Gwen Lichtman

Philip Baker Hall
Lance Strictland

Shawn Pyfrom
Trey

Joel David Moore
Pound Employee

Kevin Cooney
Doctor

Craig Kilborn
Baxter

Jeanette Brox
Janey

Rhea Seehorn
Lori

Koji Kataoka
Monk

Casey Sander
Leader

Jesse Heiman
Pound Employee (uncredited)

Mic Rodgers
Bus Driver

Eric Winzenried
Animal Control Officer

Adam Hicks
Quarterback

Crystal the Monkey
Capuchin (uncredited)