Seth Rogen
Dale Denton

James Franco
Saul Silver

Gary Cole
Ted

Danny McBride
Red

Rosie Perez
Carol

Kevin Corrigan
Budlofsky

Craig Robinson
Matheson

Amber Heard
Angie Anderson

Ed Begley Jr.
Robert

Nora Dunn
Shannon

Bobby Lee
Bobby

James Remar
General Bratt

Joe Lo Truglio
Mr. Edwards

Art Napiontek
Clark

Cleo King
Police Liaison Officer

Bill Hader
Private Miller

Jonathan Spencer
Scientist

Dana Lee
Cheung

Ken Jeong
Ken

Connie Sawyer
Faye Belogus

David McDivitt
Cop with Mole

Mae LaBorde
Mrs. Mendelson

Jeannetta Arnette
Sandra Danby

Omar Leyva
Guy in Car #2

Jack Kehler
Walter - Accountant

Robert Longstreet
Dr. Terrence

Peter Gray Lewis
Thug #1 - Peter

Steve Bannos
Thug #2 - Jared

Eddie Rouse
Thug #5 - Lance

Brian Scannell
Thug

Troy Gentile
Troy (uncredited)