Will Smith
Ben

Rosario Dawson
Emily

Woody Harrelson
Ezra Turner

Michael Ealy
Ben's Brother

Barry Pepper
Dan

Elpidia Carrillo
Connie

Robinne Lee
Sarah

Bill Smitrovich
George Ristuccia

Joe Nuñez
Larry

Sarah Jane Morris
Susan

Connor Cruise
Young Ben

Tim Kelleher
Stewart Goodman

Gina Hecht
Dr. Briar

Andy Milder
George's Doctor

Judyann Elder
Holly

Madison Pettis
Connie's Daughter

Octavia Spencer
Kate the Home Health Care Nurse

Robert Ochoa
Choirboy (uncredited)

Bojana Novaković
Julie

Sonya Eddy
Nurse