Julia Roberts
Kathleen 'Kiki' Harrison

John Cusack
Eddie Thomas

Catherine Zeta-Jones
Gwen Harrison

Billy Crystal
Lee Phillips

Hank Azaria
Hector Gorgonzolas

Stanley Tucci
Dave Kingman

Christopher Walken
Hal Weidmann

Seth Green
Danny Wax

Alan Arkin
Wellness Guide

Rainn Wilson
Dave O'Hanlon

Scot Zeller
Davis

Larry King
Self

Keri Lynn Pratt
Leaf Weidmann

Eric Balfour
Security Guard

Marty Belafsky
Security Guard

Maria Canals-Barrera
Adinah

Wendy Schenker
Maura Klein

Lisa Joyner
Laura Messinger

Byron Allen
Byron Allen

Sam Rubin
Ken

Steve Pink
Limo Driver

Shaun Robinson
Nevada Anchorwoman

Maree Cheatham
Matronly Interviewer

Alexander Enberg
Larry King Producer

Shawn Driscoll
Sean

Ann Cusack
Assistant to Lee Phillips (uncredited)

Emma Roberts
Girl in Purple T-shirt (uncredited)