Naomi Watts
Iris

Bill Murray
Walter

Ann Dowd
Marjorie

Constance Wu
Tuesday

Sarah Pidgeon
Val

Carla Gugino
Elaine

Noma Dumezweni
Barbara

Felix Solis
Hektor

Owen Teague
Carter

Bing
Apollo

Gina Costigan
Jocelyn

Josh Pais
Jerry

Cloé Xhauflaire
Camille

Susan Lynskey
Host

Joel Van Liew
Male Dinner Guest

Annie Fox
Jenna

Sue Jean Kim
Blossom

Joe Castle Baker
Young Professor

Gary Littman
Grant

Sarah Baskin
Mara

Jess Gabor
Stella

Bruce Norris
Dr. Novak

Amy Warren
Pantsuit Woman

Juliet Brett
Sophie

Afsheen Misaghi
Shervin

Seth Barrish
Harry

Ian Lithgow
Larry

Jonathan Raviv
Party Goer

Myrna Cabello
Lydia

Tom McCarthy
Dr. Warren

Gregory Abbey
Robert

Cedric Cannon
Chess Player (uncredited)

Grayson Powell
Bearded Writer (uncredited)

Alex Ziwak
New YOrk Rangers Fan (uncredited)