Forest Whitaker
Cecil Gaines

Oprah Winfrey
Gloria Gaines

David Oyelowo
Louis Gaines

John Cusack
Richard Nixon

Jane Fonda
Nancy Reagan

Cuba Gooding Jr.
Carter Wilson

Mariah Carey
Hattie Pearl

Terrence Howard
Howard

Lenny Kravitz
James Holloway

Aml Ameen
Cecil Gaines (15)

Michael Rainey Jr.
Cecil Gaines (8)

James Marsden
John F. Kennedy

Alex Pettyfer
Thomas Westfall

Vanessa Redgrave
Annabeth Westfall

Alan Rickman
Ronald Reagan

Liev Schreiber
Lyndon B. Johnson

Robin Williams
Dwight Eisenhower

Yaya DaCosta
Carol Hammie

David Banner
Earl Gaines

Colman Domingo
Freddie Fallows

Nelsan Ellis
Martin Luther King Jr.

Nealla Gordon
Senator Kassebaum

Elijah Kelley
Charlie Gaines (15-18)

Minka Kelly
Jackie Kennedy

Adriane Lenox
Gina

Mo McRae
Eldridge Huggins

Pernell Walker
Lorraine

Jesse Williams
Rev. James Lawson

Clarence Williams III
Maynard

Jim Gleason
R.D. Warner

Isaac White
Charlie Gaines (10)

Joe Chrest
White Usher

James DuMont
Sherman Adams

Robert Aberdeen
Herbert Brownell

Olivia Washington
Olivia

Danny Strong
Freedom Bus Journalist

Dana Gourrier
Helen Holloway

Colin Walker
John Ehrlichman

Alex Manette
Bob Haldeman

Stephen Rider
Admiral Rochon

Tarra Riggs
Sophie Wilson (uncredited)

Xosha Roquemore
Foxy (uncredited)