Danny DeVito
Frank Menure

Kathy Bates
Agnes Menure

Ron Livingston
Dr. Richard Clayton

Neve Campbell
Ellen Minnola

Beverly D'Angelo
Angela Minnola

Bob Odenkirk
Mitch Clayton

Edward Herrmann
Doug Clayton

Christine Baranski
Arleen Clayton

Martin Mull
Jeffry Morton

Michael McKean
Ken Hyman

M.C. Gainey
Spicer

Star Jones
Holly Davis

Ed Begley Jr.
Mr. Manoire

Debbi Morgan
Mrs. Manoire

Rose Abdoo
Frustrated Housewife

Connie Sawyer
Old Lady

Tracey Walter
Toupee Salesman

Sam Rubin
TV Anchorman

Dave Bautista
Wrestler (uncredited)

Jordan Brower
Prisoner (uncredited)

Jon Donahue
Additional voices (uncredited)

Paul Lévesque
Wrestler (uncredited)

Emo Philips
Guest at Carnival Party (uncredited)