William H. Macy
Lefty Maginnis (voice)

Rob Reiner
Screwie (voice)

Brian Dennehy
Babe Ruth (voice)

Jake T. Austin
Yankee Irving (voice)

Cherise Boothe
Rosetta Brewster (voice)

Whoopi Goldberg
Darlin' (voice)

Ed Helms
Hobo Louie (voice)

Ray Iannicelli
Conductors / Umpire (voice)

Gideon Jacobs
Bully Kid Tubby (voice)

Richard Kind
Hobo Andy / Maitre D' (voice)

Mandy Patinkin
Stanley Irving (voice)

Will Reeve
Big Kid (voice)

Raven-Symoné
Marti Brewster (voice)

Joe Torre
Yankees' Manager (voice)

Robert Wagner
Mr. Robinson (voice)

Forest Whitaker
Lonnie Brewster (voice)

Sondra James
Additional Voices (voice)

Charles Parnell
Additional Voices (voice)

Dennis T. Carnegie
Additional Voices (voice)

Jim Titus
Additional Voices (voice)

Cornell Womack
Additional Voices (voice)

Robin Williams
Napoleon Cross (uncredited)