Matthew McConaughey
Ron Woodroof

Jennifer Garner
Eve

Jared Leto
Rayon

Denis O'Hare
Dr. Sevard

Steve Zahn
Tucker

Michael O'Neill
Richard Barkley

Dallas Roberts
David Wayne

Griffin Dunne
Dr. Vass

Kevin Rankin
T.J.

Donna DuPlantier
Nurse Frazin

Deneen Tyler
Denise

J.D. Evermore
Clint

Ian Casselberry
Hispanic Orderly

Bradford Cox
Sunny

Rick Espaillat
Michael

Lawrence Turner
Foreman

Lucius Falick
Freddie

James DuMont
Rayon's Father

Jane McNeill
Francine Suskind

Matthew Thompson
Effeminate Man

Tony Bentley
Judge

Sean Boyd
Border Agent

Rachel Wulff
News Anchor

Neeona Neal
Stripper

Scott Takeda
Mr. Yamata

Jonathan Tabler
Rick Ferris

Joji Yoshida
Dr. Hiroshi

Carl Palmer
FDA Customs Agent

Martin Covert
Ian

Douglas M. Griffin
Rog

Craig Borten
Quicksilver Cowboy

Henry Frost
Gay Cowboy

Juliet Reeves London
Rodeo Girl (uncredited)

Jeanine Hill
Rodeo Girl (uncredited)

Lily Virginia Filson
Dancer (uncredited)

Steffie Grote
The Girl With The Snake Tattoo (uncredited)