Mark Burnham
Officer Duke

Steve Little
Officer Sunshine

Eric Judor
Officer Rough

Marilyn Manson
David Dolores Frank

Arden Myrin
Officer Holmes

Eric Wareheim
Officer de Luca

Grace Zabriskie
Donna (Duke's mother)

Eric Roberts
Bob

Ray Wise
Captain Andy

Jennifer Blanc
Ruth (Rough's neighbor)

Daniel Quinn
Neighbor

Hillary Tuck
Kylie (Sunshine's wife)

Don Stark
Gary

Tim Trobec
André (Ruth's husband)

Joel Bryant
Bill (Holmes' husband)

Roxane Mesquida
Girl

Kurt Fuller
Music Producer

Mary Loveless
Cashier

Flying Lotus
Customer

Steve Howey
Sandy / Michael

Agnes Bruckner
Julia Kieffer

Jon Lajoie
Officer Regan

Bob McCracken
Willy

Jack Plotnick
Special Guest

Ping Wu
Chinese

Brennan Feonix
Screw

Mona Walravens
Special Guest

Jen Nikolaisen
Sally (Stroller Mom) (uncredited)