E. G. Daily
Tommy Pickles (voice)

Christine Cavanaugh
Chuckie Finster (voice)

Cheryl Chase
Angelica Pickles (voice)

Susan Sarandon
Coco LaBouche (voice)

John Lithgow
Jean-Claude (voice)

Tara Strong
Dil Pickles (voice)

Kath Soucie
Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell
Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer
Susie Carmichael (voice)

Tress MacNeille
Charlotte Pickles (voice)

Debbie Reynolds
Lulu Pickles (voice)

Joe Alaskey
Grandpa Lou Pickles (voice)

Mako
Mr. Yamaguchi (voice)

Tim Curry
Sumo Singer (voice)

Julia Kato
Kira Watanabe-Finster (voice)

Billy West
Sumo Singer (voice)

Dionne Quan
Kimi Watanabe-Finster (voice)

Melanie Chartoff
Didi Pickles (voice)

Casey Kasem
Wedding DJ (voice)

Phil Proctor
Howard DeVille (voice)

Dan Castellaneta
Priest (voice)

Roger Rose
Finster Wedding DJ (voice)

Kevin Michael Richardson
Sumo Singer (voice)

Jack Riley
Stu Pickles (voice)