Jeff Bridges
Dr. Mark Powell

Kevin Spacey
Prot

Mary McCormack
Rachel Powell

Alfre Woodard
Claudia Villars

David Patrick Kelly
Howie

Saul Williams
Ernie

Peter Gerety
Sal

Celia Weston
Mrs. Archer

Ajay Naidu
Dr. Chakaraborty

Tracy Vilar
Maria

John Toles-Bey
Russell

Kimberly Scott
Joyce Trexler

Conchata Ferrell
Betty McAllister

Vincent Laresca
Navarro

Mark Christopher Lawrence
Simms

Brian Howe
Steve Becker

Mary Mara
Abby

Brandon de Paul
Josh - Age 10

Aaron Paul
Michael Powell - Age 21

William Lucking
Sheriff

Kelly Connell
Walter Fleen

Peter Maloney
Duncan Flynn

Lance E. Nichols
David Patel

Paul Linke
Stuart Hessler

Greg Lewis
Dominic McAllister

Clarke Peters
Homeless Veteran

Olga Merediz
Transit Officer

Joe Holt
Transit Officer

Lola Pashalinski
Russian Woman

Kateri Walker
Sara Porter

Katya Abelski
Rebecca Porter

Norman Alden
Babbling Man

Rawle D. Lewis
Security Guard

Erik LaRay Harvey
Security Guard

Vince Cupone
Thug

Anne Carroll
Ward Patient

Pat Jankiewicz
Ward Patient

Joseph Steven
Ward Patient

Coco Leigh
Ward Patient

Julie Sands
Ward Patient

Curt Clendenin
Hospital Patient (uncredited)

Frank Collison
Screaming Man (uncredited)

Paulo Pascoal
Thief (Uncredited)

Randy Springer
Lab Tech (uncredited)