Danny Glover
Lieutenant Mike Harrigan

Gary Busey
Peter Keyes

Rubén Blades
Danny Archuleta

María Conchita Alonso
Leona Cantrell

Bill Paxton
Jerry Lambert

Robert Davi
Captain Phil Heinemann

Adam Baldwin
Garber

Kevin Peter Hall
The Predator

Kent McCord
Captain B. Pilgrim

Morton Downey, Jr.
Tony Pope

Calvin Lockhart
King Willie

Steve Kahan
Sergeant

Henry Kingi
El Scorpio

Elpidia Carrillo
Anna

Lilyan Chauvin
Irene Edwards

Teri Weigel
Colombian Girl

John Cann
Subway Gang

Michael Papajohn
Subway Gang

Louis Eppolito
Patrolman

Charles Haugk
Charlie

Sylvia Kauders
Ruth

Charles David Richards
Commuter

Julian Reyes
Juan Beltran

Casey Sander
Federal Team

Pat Skipper
Federal Team

David Starwalt
Reporter

Abraham Alvarez
Reporter

Jim Ishida
Reporter

George Christy
Reporter

Lucinda Weist
Reporter

Richard Anthony Crenna
Paramedic

Billy 'Sly' Williams
Paramedic

Paulo Tocha
Detective

Jsu Garcia
Detective

Tom Finnegan
Officer

Vonte Sweet
Sweet

Brian Levinson
Brian

Michael Wiseman
Cop

Thomas Rosales Jr.
El Scorpio Gang Member (uncredited)

Hal Rayle
The Predator (voice) (uncredited)

Manny Perry
King Willie Gang Member (uncredited)

Philip Weyland
Man in Crushed Car (uncredited)

Ron Stein
Train Passenger (uncredited)

Thomas Rosales Jr.
El Scorpio Gang Member