Robert Downey Jr.
Steve Lopez

Jamie Foxx
Nathaniel Ayers

Catherine Keener
Mary Weston

Tom Hollander
Graham Claydon

Nelsan Ellis
David Carter

Michael Bunin
Adam Crane

LisaGay Hamilton
Jennifer Ayers

Rachael Harris
Leslie Bloom

Stephen Root
Curt Reynolds

Lorraine Toussaint
Flo Ayers

Jena Malone
Cheery Lab Tech

Octavia Spencer
Troubled Woman

Justin Martin
Young Nathaniel

Patrick Tatten
Paul Jr.

Susane Lee
Marisa

Marcos De Silvas
Mayor Villaigosa

Ilia Volok
Harry Barnoff

Moya Brady
Barely Dressed Woman

Orlando Ashley
LAMP Homeless Guy

Artel Great
Leon

J.J. Boone
Shouting Woman

Tony Genaro
Globe Lobby Guard

Charlie Weirauch
Atheist

Wayne Lopez
Cop with Tents

Joe Hernandez-Kolski
EMT #1

Noel Gugliemi
Winston Street Cop

Wil Garret
Homeless Man

Alejandro Patiño
Construction Worker

Karole Selmon
Homeless Woman #1

Rob Nagle
Neil

Patricia Place
Cello Donor

Ralph Cole Jr.
Enraged Homeless Man

Palma Lawrence Reed
ER Nurse

Troy Blendell
News Editor

Nick Nervies
Jennifer's Son

Paul Norwood
Editor

Wally Lozano
Sign Spinner (uncredited)

Siso Kamburov
Disney Hall Patron (uncredited)