Colin Farrell
Alexander

Angelina Jolie
Olympias

Val Kilmer
Philip

Jared Leto
Hephaistion

Jonathan Rhys Meyers
Cassander

Anthony Hopkins
Old Ptolemy

Jessie Kamm
Young Alexander

Christopher Plummer
Aristotle

Connor Paolo
Young Alexander

Peter Williamson
Young Nearchus

Morgan Christopher Ferris
Young Cassander

Rob Earley
Young Ptolemy

Aleczander Gordon
Young Perdiccas

John Kavanagh
Parmenion

Gary Stretch
Cleitus

Rosario Dawson
Roxane

Toby Kebbell
Pausanius

Fiona O'Shaughnessy
Nurse

Laird Macintosh
Greek Officer

Francisco Bosch
Bagoas

Neil Jackson
Perdiccas

Rory McCann
Crateros

Raz Degan
Darius III

Joseph Morgan
Philotas

David Bedella
Scribe

Brian Blessed
Wrestling Trainer

Nick Dunning
Attalus

Elliot Cowan
Ptolemy

Ian Beattie
Antigonus

Denis Conway
Nearchus

Michael Dixon
Campfire Soldier

Tim Pigott-Smith
Omen Reader

Erol Sander
Persian Prince

Stéphane Ferrara
Bactrian Commander

Tadhg Murphy
Dying Soldier

Annelise Hesme
Stateira

Marie Meyer
Eurydice

Mick Lally
Horse Seller

Garrett Lombard
Leonnatus

Rab Affleck
Attalus' Henchman

Féodor Atkine
Roxane's Father

Bin Bunluerit
Indian King

Jaran Ngamdee
Indian Prince

Brian McGrath
Doctor

Michelle Lukes
Roxane Dancer

Anjali Mehra
Roxane Dancer

Benny Maslov
Bagoas Dancer

Benjamín Benítez
Amato (uncredited)

Nicolas D. Blake
Palace Page (uncredited)

Max Bollinger
Young Greek Official (uncredited)

Jason Croot
Peasant (uncredited)

Dale Dye
Macedonian Veteran at Hyphasis Speech (uncredited)

Abbie Hirst
Octavia (uncredited)

Rowley Irlam
Pausanius's Accomplice (uncredited)

David Leon
Hermolaous (uncredited)

Greg Orvis
Celtic Diplomat (uncredited)

Lee Anthony Parnell
Warrior (uncredited)

John Reynolds
Dexapous (uncredited)

Oliver Stone
Macedonian Soldier at Zeus Statue (uncredited)