Malcolm McDowell
Dr. Samuel Loomis

Sheri Moon Zombie
Deborah Myers

Tyler Mane
Michael Myers

Scout Taylor-Compton
Laurie Strode

Brad Dourif
Sheriff Lee Brackett

Danielle Harris
Annie Brackett

Hanna Hall
Judith Myers

Daeg Faerch
Michael Myers, Age 10

Kristina Klebe
Lynda

Danny Trejo
Ismael Cruz

Ken Foree
Big Joe Grizzly

Udo Kier
Morgan Walker

Sid Haig
Chester Chesterfield

Daryl Sabara
Wesley Rhoades

Daniel Roebuck
Lou Martini

Richard Lynch
Principal Chambers

William Forsythe
Ronnie White

Clint Howard
Doctor Koplenson

Lew Temple
Noel Kluggs

Tom Towles
Larry Redgrave

Bill Moseley
Zach "Z-Man" Garrett

Leslie Easterbrook
Patty Frost

Steve Boyles
Stan Payne

Skyler Gisondo
Tommy Doyal

Adam Weisman
Steve

Dee Wallace
Cynthia Strode

Max Van Ville
Paul

Nick Mennell
Bob Simms

Pat Skipper
Mason Strode

Richmond Arquette
Deputy Charles

Sybil Danning
Nurse Wynn

Micky Dolenz
Derek Allen

Mel Fair
Taylor Madison

Andreana Weiner
Voice Performer (voice)

David Michie
Voice Performer (voice)

Jeremy Maxwell
Voice Performer (voice)

Barbara Harris
Voice Performer (voice)

Noreen Reardon
Voice Performer (voice)

John DeMita
Voice Performer (voice)

Nancy Truman
Voice Performer (voice)

Daamen J. Krall
Voice Performer (voice)

Courtney Gains
Jack Kendall (uncredited)

Ezra Buzzington
Graveyard Keeper (uncredited)

Gary Grossman
Drunk "Rabbit in Red" Patron (uncredited)

Kazu Nagahama
College Student (uncredited)

Olja Hrustic
Raped Inmate (uncredited)

Richard Fancy
University Dean (uncredited)