Chris Massoglia
Darren Shan

John C. Reilly
Larten Crepsley

Josh Hutcherson
Steve

Patrick Fugit
Evra the Snake Boy

Salma Hayek Pinault
Madame Truska

Jessica Carlson
Rebecca

Michael Cerveris
Mr. Tiny

Ray Stevenson
Murlaugh

Morgan Saylor
Annie

Don McManus
Mr. Shan

Ken Watanabe
Mr. Tall

Orlando Jones
Alexander Ribs

Frankie Faison
Rhamus Twobellies

Willem Dafoe
Gavner Purl

Kristen Schaal
Gertha Teeth

Patrick Breen
Mr. Kersey

Tom Woodruff Jr.
Wolfman

Jane Krakowski
Corma Limbs

Drew Rin Varick
Loaf Head

Colleen Camp
Mrs. Shan

Lo Graham
Student in Hallway and Classroom

Beau Holden
Trucker

Trey Burvant
Singing Dad

Daniel Newman
Pete

Brandon Molale
Vampaneze (uncredited)

Gino Galento
Madame Truska's Man (uncredited)

Sam Medina
Madame Truska's Man (uncredited)

Cody Klop
Voice