Jane Krakowski
Claire's Mom

Richard Griffiths
Santa Claus

Steve Whitmire
Kermit the Frog / Rizzo the Rat / Statler / Beaker (voice)

Madison Pettis
Claire

Whoopi Goldberg
Taxi Driver

Dave Goelz
The Great Gonzo / Waldorf / Dr. Bunsen Honeydew / Zoot (voice)

Bill Barretta
Pepe the Prawn / Swedish Chef / Rowlf / Dr. Teeth / Bobo the Bear / Husband Pigeon (voice)

Michael Bloomberg
Himself (as Mayor Michael Bloomberg)

Eric Jacobson
Fozzie Bear / Miss Piggy / Animal / Sam the Eagle (voice)

Matt Vogel
Floyd Pepper / Lew Zealand / Crazy Harry / Robin the Frog / Son Pigeon / Additional Muppets (voice)

David Rudman
Scooter / Janice / Additional Muppets (voice)

Nathan Lane
Officer Meany

Jesse L. Martin
Postal Worker

Petra Němcová
Beaker's Girlfriend

Steve Schirripa
Mobster

Tony Sirico
Mobster

Uma Thurman
Joy

Paul Williams
Elf

Pam Arciero
Additional Muppets (voice)

Heather Asch
Additional Muppets (voice)

Tyler Bunch
Wife Pigeon / Additional Muppets (voice)

Leslie Carrara-Rudolph
Additional Muppets (voice)

Stephanie D'Abruzzo
Additional Muppets (voice)

James Godwin
Additional Muppets (voice)

James J. Kroupa
Additional Muppets (voice)

Tim Lagasse
Additional Muppets (voice)

Peter Linz
Additional Muppets (voice)

Noel MacNeal
Sweetums / Additional Muppets (voice)

Jim Martin
Additional Muppets (voice)

Paul McGinnis
Additional Muppets (voice)

Martin P. Robinson
Sweetums / Additional Muppets (voice)

Nadine Ellis
Dancer

Kevin Sateri
Dancer

Paul Becker
Postal Dancer

Bill Timoney
Additional Voices