David Mattey
Toxic Avenger / Noxious Offender

Debbie Rochon
Ms. Weiner

Ron Jeremy
Mayor Goldberg

Tom Fulp
Painter

Stan Lee
Prologue / Epilogue Narrator (voice)

Joe Fleishaker
Chester / Lardass

Dan Snow
Sgt. Kazinski

Corey Feldman
Sarah's Gynecologist

Trent Haaga
Tex Diaper

Mark Torgl
Evil Melvin

Rick Collins
Amortville Police Chief

Mitch Cohen
Lucifer

Lisa Gaye
Abortion Counselor

James Gunn
Dr. Flem Hocking

Al Goldstein
Press Secretary

Taylor Mead
Award Presenter

Will Keenan
Man Hit by Car

Jasi Cotton Lanier
Wet Lesbian

Lemmy Kilmister
Good Lemmy / Bad Lemmy

Julie Strain
Herself (Facelift Death)

Kevin Eastman
Himself (Breast Smoosh Death)

Tiffany Shepis
Beautiful Interpretative Dancer

Eli Roth
Beautiful Young Boy

Hugh Hefner
President of the United States

Charlotte Kaufman
Tromaville / Amortville Citizen

Lloyd Kaufman
Man in Public Service Announcement

Neriah Davis
Glamorous Gyno-American

Devin DeVasquez
Glamorous Gyno-American

Taimie Hannum
Glamorous Gyno-American

Masuimi Max
Glamorous Gyno-American

Doria Rone
Glamorous Gyno-American

Petra Verkaik
Glamorous Gyno-American

Brandi Brandt
Glamorous Gyno-American

Randy Sklar
Randy Diaz

Jason Sklar
Jason Gonzalez