Ian McKellen
Sherlock Holmes

Laura Linney
Mrs. Munro

Milo Parker
Roger

Hiroyuki Sanada
Tamiki Umezaki

Roger Allam
Dr. Barrie

Frances de la Tour
Madame Schirmer

Hattie Morahan
Ann Kelmot

Phil Davis
Inspector Gilbert

Patrick Kennedy
Thomas Kelmot

John Sessions
Mycroft Holmes

Frances Barber
Matinee "Madame Schirmer"

Charles Maddox
Oswald

Takako Akashi
Maya Umezaki

Michael Culkin
Bank Manager

Oliver Devoti
Ticket Agent

Nicholas Rowe
Matinee "Sherlock Holmes"

Hermione Corfield
Matinee "Ann Kelmot"

Kit Connor
Boy

Zoe Rainey
Boy's Mother

Eileen Davies
Lady on Platform

Sarah Crowden
Mrs. Hudson

Johnny Otto
Army Officer (uncredited)

Paul Blackwell
Station Passenger