Clark Gable
Edward J. 'Blackie' Gallagher

William Powell
Jim Wade

Myrna Loy
Eleanor Packer

Leo Carrillo
Father Joe

Nat Pendleton
Spud

George Sidney
Poppa Rosen

Isabel Jewell
Annabelle

Muriel Evans
Tootsie Malone

Thomas E. Jackson
Asst. Dist. Atty. Richard Snow

Isabelle Keith
Miss Adams

Noel Madison
Manny Arnold

Jimmy Butler
Jim Wade as a Boy

Mickey Rooney
Blackie as a Boy

Shirley Ross
Singer in Cotton Club

Donald Haines
Young Spud (uncredited)

Frank Conroy
Blackie's Defense Attorney (uncredited)

Leonid Kinskey
Trotskyite Slapping Poppa Rosen

Oscar Apfel
Speaker of Assembly (uncredited)

William Bailey
Al Barnes (uncredited)

Curtis Benton
Announcer (uncredited)

John Bleifer
Chauffeur (uncredited)

Vernon Dent
Otto (uncredited)

Jay Eaton
Drunk (uncredited)

John Marston
Mr. Coates (uncredited)

Jack 'Tiny' Lipson
Uncle Angus (uncredited)

Lew Harvey
Craps Dealer (uncredited)

Samuel S. Hinds
Warden of Sing Sing (uncredited)

Wade Boteler
Prison Guard (uncredited)

Sam McDaniel
Black Prisoner on Death Row (uncredited)

G. Pat Collins
Killer in Prison (uncredited)

Charles R. Moore
Black Man in Speakeasy (uncredited)

Don Brodie
Reporter (uncredited)

George Irving
Jim's Campaign Manager (uncredited)

Pete Smith
Racetrack Announcer (Voice) (uncredited)

Al Thompson
Street Spectator (uncredited)

Edward Van Sloan
Yacht Captain Swenson (uncredited)

Dorothy Vernon
Boat Passenger (uncredited)

Mary Gordon
Boat Passenger (uncredited)

William Irving
German Note Holder (uncredited)

Bert Sprotte
German Note Holder (uncredited)

William Stack
Judge (uncredited)

Lee Phelps
Bailiff (uncredited)

Landers Stevens
Inspector (uncredited)

Stanley Blystone
Detective in Court (uncredited)

Tom McGuire
Policeman in Court (uncredited)

Jack Kenney
Policeman (uncredited)

Lee Shumway
Policeman (uncredited)

Stanley Taylor
Police Intern (uncredited)

Emmett Vogan
Assistant District Attorney (uncredited)