Matthew Modine
Joe

Catherine Keener
Mary

Daryl Hannah
Kelly

Maxwell Caulfield
Bob

Elizabeth Berkley
Tina

Marlo Thomas
Blair

Bridgette Wilson-Sampras
Sahara

Buck Henry
Dr. Leuter

Christopher Lloyd
Ernst

Kathleen Turner
Dee Dee Taylor

Denis Leary
Doug

Beatrice Winde
Wilma

John Tormey
Harassing Man

Ali Wentworth
Raina

Debra McGrath
Cis

Nahanni Johnstone
Young Woman

Alex Appel
Sheila

Steve Buscemi
Nick

Dave Chappelle
Zee

Landy Cannon
Beach Boy

Katie Griffin
Empty V Interviewer

Missy Yager
Lisa

Daniel von Bargen
Devon