Melanie Griffith
Patty Palmer

Matthew Modine
Drake Goodman

Michael Keaton
Carter Hayes / James Danforth

Mako
Toshio Watanabe

Nobu McCarthy
Mira Watanabe

Laurie Metcalf
Stephanie MacDonald

Carl Lumbly
Lieutenant Lou Baker

Dorian Harewood
Dennis

Luca Bercovici
Greg

Tippi Hedren
Florence Peters

Sheila McCarthy
Liz Hamilton

Guy Boyd
Warning Cop

Jerry Hardin
Bennett Fidlow

Dan Hedaya
Loan Officer

James Staley
District Attorney Henry

Miriam Margolyes
Realtor

Takayo Fischer
Bank Teller

F. William Parker
Judge Mitchell Black

Nicholas Pryor
Hotel Front Office Manager Neil Spisak

Tony Simotes
Desk Clerk Victor

O-Lan Jones
Motel Maid Patricia

Seth Isler
Sergeant Bobby Amato

Dabbs Greer
Mr. Thayer

Florence Sundstrom
Mrs. Thayer

Noel Evangelisti
Mrs. Smith

Nick Rutherford
Child

Tom Nolan
Bank Teller

Hal Landon Jr.
2nd Deputy Sheriff

Hy Anzell
Locksmith Manford Bagel

Tracey Walter
Exterminator

William Paterson
Mr. Hill

D.W. Moffett
Bill

Barbara Tyson
Amy

Bud Ekins
Thug

Danny Wynands
Thug

David Lloyd Wilson
Television Host

Alice Barden
Neighbor

Tohoru Masamune
Neighbor

Linda Austin
Neighbor

Beverly D'Angelo
Ann Miller (uncredited)

John Schlesinger
Man in Elevator (uncredited)