Hayley Mills
Pollyanna

Jane Wyman
Aunt Polly

Richard Egan
Dr. Edmond Chilton

Karl Malden
Reverend Paul Ford

Nancy Olson
Nancy Furman

Adolphe Menjou
Mr. Pendergast

Donald Crisp
Mayor Karl Warren

Agnes Moorehead
Mrs. Snow

Kevin Corcoran
Jimmy Bean

James Drury
George Dodds

Reta Shaw
Tillie Lagerlof

Leora Dana
Mrs. Ford

Anne Seymour
Amelia Tarbell

Edward Platt
Ben Tarbell

Mary Grace Canfield
Angelica

Jenny Egan
Mildred Snow

Gage Clarke
Mr. Murg

Ian Wolfe
Mr. Neely

Nolan Leary
Mr. Thomas

Edgar Dearing
Mr. Gorman

Arthur Tovey
Fishing Booth Attendant (Uncredited)

Paul Frees
Barker (Voice) (Uncredited)

Harry Harvey
Editor (Uncredited)

Jon Lormer
Mr. Geary (Uncredited)

William Newell
Mr. Hooper (Uncredited)

George Sowards
Wagon Driver (Uncredited)

David Swift
Fireman (Uncredited)