Benjamin Bratt
Superman / Hernan Guerra (voice)

Michael C. Hall
Batman / Kirk Langstrom (voice)

Tamara Taylor
Wonder Woman / Bekka (voice)

Jason Isaacs
Lex Luthor (voice)

C. Thomas Howell
Dr. Will Magnus (voice)

Paget Brewster
Lois Lane (voice)

Kari Wahlgren
Karen Beecher / Livewire (voice)

Grey DeLisle
Tina / Platinum (voice)

Larry Cedar
Pete Ross (voice)

Eric Bauza
Ryan Choi / Stephen Shin (voice)

Penny Johnson Jerald
President Waller (voice)

Dee Bradley Baker
Ray Palmer / Tin (voice)

Richard Chamberlain
Highfather (voice)

Trevor Devall
Emil Hamilton (voice)

Dan Gilvezan
Pat Dugan (voice)

Daniel Hagen
Dr. Sivana (voice)

Josh Keaton
Orion (voice)

Arif S. Kinchen
Michael Holt / Bronze Tiger (voice)

Yuri Lowenthal
Jor-El / Jimmy Olsen (voice)

Carl Lumbly
Silas Stone (voice)

Jim Meskimen
Victor Fries (voice)

Tayla Parx
Victor Stone (voice)

Khary Payton
John Henry Irons / Granny Goodness / Mugger (voice)

Tahmoh Penikett
Steve Trevor (voice)

Andrea Romano
Jean Palmer (voice)

André Sogliuzzo
Cop / Mr. Guerra (voice)

Bruce Thomas
General Zod / Darkseid (voice)

Lauren Tom
Lara Lor-Van (voice)

Marcelo Tubert
Tough Guy (voice)

Bruce Timm
Blockbuster (voice) (uncredited)