Steve Carell
Gru / Dru (voice)

Kristen Wiig
Lucy Wilde (voice)

Trey Parker
Balthazar Bratt (voice)

Miranda Cosgrove
Margo (voice)

Dana Gaier
Edith (voice)

Nhev Scharrel
Agnes (voice)

Pierre Coffin
Mel / Minions / Museum Director / Additional Voices (voice)

Steve Coogan
Fritz / Silas Ramsbottom (voice)

Julie Andrews
Gru’s Mom (voice)

Jenny Slate
Valerie Da Vinci (voice)

Michael Beattie
Scar-Faced Man / TMZ Announcer (voice)

Andy Nyman
Clive the Robot (voice)

Adrian Ciscato
Niko (voice)

Brian T. Delaney
Commercial Announcer / Military Officer / Additional Voice (voice)

Ken Daurio
Celebrity (voice)

Cory Walls
Vincenzo (voice)

Lori Alan
Additional Voices (voice)

Carlos Alazraqui
Additional Voices (voice)

Kyle Balda
Additional Voices (voice)

Bob Bergen
Additional Voices (voice)

Gregg Berger
Additional Voice (voice)

John Cygan
Additional Voice (voice)

Bill Farmer
Additional Voices (voice)

Danny Mann
Additional Voices (voice)

Bruno Dequier
Additional Voice (voice)

Teresa Ganzel
Additional Voices (voice)

Jess Harnell
Additional Voices (voice)

John Kassir
Additional Voice (voice)

Mona Marshall
Additional Voice (voice)

Laraine Newman
Additional Voice (voice)

Jan Rabson
Additional Voices (voice)

Mindy Sterling
Additional Voice (voice)

Tara Strong
Additional Voices (voice)

Jim Ward
Additional Voice (voice)

Gregg Berger
Additional Voices (voice)

Chris Renaud
Additional Minions (voice) (uncredited)

Matthew Wood
Additional Voice (voice) (uncredited)