Tom Cruise
Barry Seal

Domhnall Gleeson
Monty 'Schafer'

Sarah Wright
Lucy Seal

Jesse Plemons
Sheriff Downing

Caleb Landry Jones
JB

Lola Kirke
Judy Downing

Jayma Mays
Dana Sibota

Alejandro Edda
Jorge Ochoa

Benito Martinez
James Rangel

E. Roger Mitchell
Agent Craig McCall

Jed Rees
Louis Finkle

Mauricio Mejía
Pablo Escobar

Robert Farrior
Oliver North

Morgan Hinkleman
Christina

Daniel Lugo
Adolfo Calero

Jayson Warner Smith
Bill Cooper (Snowbird #1)

William Mark McCullough
Pete (Snowbird #2)

April Billingsley
Stewardess

Lauren Boyd
Secretary

Lauren Revard
Teller

Marcus Hester
Parka

Mike Pniewski
Willie (State Police)

Frank Licari
DEA Agent #1

Alex Collins
ATF #1

Scott Poythress
ATF #2

Connor Trinneer
George W. Bush / Texan

Alpha Trivette
Judge Linkletter

Kevin L. Johnson
Agent Horace Wainwright

Leon Lamar
Elderly Man

Tony Guerrero
Federico Vaughan

Maria Howell
NSC Woman

Darla Delgado
Customs Agent

Justice Leak
DEA Agent Winter

Robert Pralgo
Gary (Cubicle Mate)

Mickey Sumner
North's Aide Fawn Hall

Daniel Thomas May
CIA Man

Chloe Swan Sparwath
LeAnn

Byron Wigfall
Contra #1

Matt Mercurio
FBI Analyst

Jairo Ordóñez
Scar

Stephen Conroy
Military Police / Advisor

Lara Grice
Female Reporter (uncredited)

Sharon Conley
DEA Agent Grace (uncredited)

Chris Gann
Donor #2 (uncredited)

Johnny Otto
Pilot (uncredited)

Kayla Perkins
Waitress (uncredited)

Michael Mercaldi
Sandinista (uncredited)

Dan Southworth
Agent Winters (uncredited)

Ronald Reagan
Self (archive footage) (uncredited)

Muhammad Ali
Self (archive footage) (uncredited)

Nancy Reagan
Self (archive footage) (uncredited)