Uma Thurman
Sissy Hankshaw

Lorraine Bracco
Delores Del Ruby

Pat Morita
The Chink

Angie Dickinson
Miss Adrian

Keanu Reeves
Julian Gitche

John Hurt
The Countess

Rain Phoenix
Bonanza Jellybean

Ed Begley Jr.
Rupert

Carol Kane
Carla

Sean Young
Marie Barth

Crispin Glover
Howard Barth

Roseanne Barr
Madame Zoe

Buck Henry
Dr. Dreyfus

Grace Zabriskie
Mrs. Hankshaw

Ken Kesey
Sissy's Daddy

Ken Babbs
Sissy's Uncle

Allen Arnold
Lionel

Victoria Williams
Cowgirl Debbie

Heather Graham
Cowgirl Heather

Udo Kier
Commercial Director

Tom Peterson
Crewman

Eric Hull
White House Undersecretary

Lin Shaye
Rubber Rose Maid

Chel White
Brain Surgeon

Scott Patrick Green
Pilgrim Man

William S. Burroughs
Self

Tom Robbins
Narrator (voice)

Roger Bowen
Naturalist (uncredited)

Edward James Olmos
Musician at Barbecue (uncredited)