Will Forte
MacGruber

Kristen Wiig
Vicki

Ryan Phillippe
Piper

Powers Boothe
Colonel Faith

Maya Rudolph
Casey

Chris Irvine
Frank Korver

Mark Henry
Tut Beemer

Glenn Jacobs
Tanker Lutz

Dalip Singh
Tug Phelps

Hassan Hamin Assad
Vernon Freedom

Paul Wight
Brick Hughes

Timothy V. Murphy
Constantine

Andy Mackenzie
Hoss

Jasper Cole
Zeke

Val Kilmer
Cunth

Rhys Coiro
Yerik Novikov

Brandon Trost
Brick's Boyfriend

Marielle Heller
Clocky

Derek Mears
Large Henchman

Vic Browder
Control Room Guard

Russ Dillen
Commander

Gregory Alan Williams
Minister

Chad Brummett
Military Officer

Amar'e Stoudemire
Self

Brian Petsos
Dude

Alan D'Antoni
Russian Guard

Cajardo Lindsey
Railroad Guard #1

Laurence Chavez
Railroad Guard #2 / Compound Guard #2

Michael Owen
Railroad Bodyguard

Ed Duran
Compound Guard #1

Bobby Burns
Compound Guard #4

Bill Leaman
Compound Guard #5

Alan Tafoya
Charging Guard

Michelle Waterson-Gomez
Club Babe #1

Jason Trost
Smoking Guard

Christina Rouner
News Anchor

Jesus Jr.
Edwin Culebra (uncredited)

Casey Messer
Cunth's Daughter (uncredited)