Martin Lawrence
Malcolm / Big Momma

Brandon T. Jackson
Trent / Charmaine

Jessica Lucas
Haley

Michelle Ang
Mia

Portia Doubleday
Jasmine Lee

Emily Rios
Isabelle

Ana Ortiz
Headmistress

Henri Lubatti
Vlad

Lorenzo Pisoni
Dmitri

Tony Curran
Chirkoff

Marc John Jefferies
Rembrandt

Brandon Gill
Scratch

Zack Mines
Delante

Rhett Lindsey
TJ

Ken Jeong
Mailman

Max Casella
Canetti

Susan Walters
Mall Mother

Sherri Shepherd
Beverly Townsend

Susan Griffiths
Cafeteria Girl #1

Brianne Gould
Cafeteria Girl #2

Dawntavia Marrero
Cafeteria Girl - Another Girl

Mari Morrow
Dance Instructor

Susie Spear Purcell
Art Teacher

Jasmine Burke
Drama Queen #2

Juliet Kim
Quad Student

Brian Lafontaine
Crawford

Ramsey Luke
FBI Agent

Jazmia Battle
Diva #1

Christiani Pitts
Diva #2

C.J. Perry Barnyashev
Dancer (uncredited)

Nilsa Castro
Audience Spectator (uncredited)

Chenique Charmaine
Cafeteria Dancer (uncredited)

Reginald Lashaun Clay
FBI Agent (uncredited)

Sarah Reagin Clemmensen
Art student (uncredited)

Rodney Edwards
Lug Head (uncredited)

Keith Allen Hayes
Parent (uncredited)

Alphonse A. Lambert, Jr.
Parent (uncredited)

Faizon Love
Kurtis Kool (uncredited)

Thina Lowe
Student (uncredited)

Carmen Matheny
Core Student (uncredited)

Chantal Maurice
Cafeteria Dancer (uncredited)

Ken Melde
Russian Mobster (uncredited)

Rachelle Neal
Girls School Dancer (uncredited)

Katherine Neslund
High School Student (uncredited)

Lexi Noel
Student Dancer (uncredited)

Kayla Perkins
Student (uncredited)

Greg Perrow
Football Player (uncredited)

Justin Price
Lug Head (uncredited)

Cody Rowlett
Russian (uncredited)

Joshua Tanksley
Audience Member (uncredited)

Lisa Marie Thomas
H.S. Arts Student (uncredited)

Steve Warren
GGSA Showcase Audience Member (uncredited)

Deonna Young
Dancer (uncredited)