Owen Wilson
Marmaduke (voice)

Emma Stone
Mazie (voice)

George López
Carlos (voice)

Caroline Sunshine
Barbara Winslow

Finley Jacobsen
Brian Winslow

Steve Coogan
Raisin (voice)

Christopher Mintz-Plasse
Giuseppe (voice)

Fergie
Jezebel (voice)

Kiefer Sutherland
Bosco (voice)

Lee Pace
Phil Winslow

Judy Greer
Debbie Winslow

Damon Wayans Jr.
Thunder (voice)

Marlon Wayans
Lightning (voice)

Sam Elliott
Chupadogra (voice)

William H. Macy
Don Twombly

David Walliams
Anton Harrison

Glenn McCuen
Bodie

Raugi Yu
Drama Trainer

Chris Colfer
Drama Dog #2 (voice)

Josh Gad
Bandana Dog (voice)

Ash Lee
Male Executive

Heather Doerksen
Female Executive

Madison Desjarlais
Brunette Girl

Nicole Muñoz
3rd OC Girl

Jason Bryden
Man on Bench

Frank Topol
Buff Owner

Izaak Smith
Basketball Captain

Keith Dallas
Emergency Road Worker

P.J. Prinsloo
Lead Fireman

Colin Decker
Fireman

Charles Jarman
Fireman

Garvin Cross
Fireman

Chris Bradford
Fireman

Hope Levy
Afghan #1 (voice)

Anjelah Johnson-Reyes
Afghan #2 (voice)

Devon Werkheiser
Drama Dog #1 / Shroom Dog #2 / Golden Dog / Cocker Spaniel (voice)

Hudson Thames
Delinquent Dog (voice)

Francisco Ramos
Purse Dog #1 (voice)

Bernardo de Paula
Purse Dog #2 (voice)

Eddie 'Piolin' Sotelo
Purse Dog #3 (voice)

Jack McGee
Dalmatian (voice)

Liza Lapira
Party Dog #1 (voice)

King Kedar
Surfing Award Dog / Beach Dog #4 (voice)

Todd Glass
Doberman / Shasta (voice)

Ryan Devlin
Beach Dog #2 (voice)

Jeffrey Garcia
Beach Dog #3 (voice)