John Wayne
John Chisum

Forrest Tucker
Lawrence Murphy

Christopher George
Dan Nodeen

Ben Johnson
James Pepper

Glenn Corbett
Pat Garrett

Andrew Prine
Alex McSween

Bruce Cabot
Sheriff Brady

Patric Knowles
Henry Tunstall

Richard Jaeckel
Jess Evans

Lynda Day George
Sue McSween

Geoffrey Deuel
Billy 'The Kid' Bonney

Pamela McMyler
Sallie Chisum

John Agar
Amos Patton

Lloyd Battista
Neemo

Robert Donner
Bradley Morton

Christopher Mitchum
Tom O'Folliard

Edward Faulkner
James J. Dolan

Ray Teal
Justice J.B. Wilson

Ron Soble
Charley Bowdre

John Mitchum
Baker

Glenn Langan
Colonel Nathan Dudley

Alan Baxter
Gov. Sam Axtell

Alberto Morin
Juan Delgado

William Bryant
Jeff - Head Wrangler

Pedro Armendáriz Jr.
Ben

John Pickard
Sgt. Braddock

Abraham Sofaer
Chief White Buffalo

Gregg Palmer
Karl Riker

Hank Worden
Stationmaster Elwood

Pedro Gonzalez Gonzalez
Mexican Rancher

Eddy Donno
Cass

Bob Morgan
Pegleg on Street

William Conrad
Narrator - Opening Credits (voice) (uncredited)

José Ángel Espinosa 'Ferrusquilla'
Governor's Aide (uncredited)

Cliff Lyons
Wrangler (uncredited)

Josh McLaglen
Young Boy Loading Wagon (uncredited)

Mary McLaglen
Young Girl (uncredited)

Lee Meriwether
Sallie's Mother (picture in Chisum's Pocketwatch) (uncredited)

Chuck Roberson
Trail Herder (uncredited)

José Torvay
Mexican Blacksmith (uncredited)

José Trinidad Villa
Blacksmith (uncredited)

Ralph Volkie
Blacksmith (uncredited)

Henry Wills
Extra (uncredited)