Donald Sutherland
Brother Thadeus

John Heard
Brother Timothy

Andrew McCarthy
Michael Dunn

Mary Stuart Masterson
Danni

Kevin Dillon
Rooney

Malcolm Danare
Caesar

Jennifer Dundas
Boo

Kate Reid
Grandma

Wallace Shawn
Father Abruzzi

Jay Patterson
Brother Constance

Dana Barron
Janine

John Eric Bentley
First Man

Philip Bosco
Brother Paul

Patrick Dempsey
Corbet

Christopher Durang
Priest

Stephen Geoffreys
Williams

Richard Hamilton
Grandpa

Vic Polizos
Police Officer

Douglas Seale
Brother Domenic

Yeardley Smith
Cathleen

Jimmie Ray Weeks
Danni's Father

Mel Winkler
Willie

Craig Austin
High School Student (uncredited)

Nancy Cartwright
Girl at Dance (uncredited)

Kathleen Gati
Catholic School Girl (uncredited)

George Gerard
High School Student (uncredited)

Jared Simon
Prep Student (uncredited)

Thomas E. van Dell
Student (uncredited)

Maggie Wagner
Catholic School Girl (uncredited)