Susan Sarandon
Rose Collins

Paul Walker
Mike Riley

Penélope Cruz
Nina Vasquez

Alan Arkin
Artie

Marcus Thomas
Jules Calvert

Sonny Marinelli
Dennis

Daniel Sunjata
Marco

Chazz Palminteri
Arizona

Robin Williams
Charlie Boyd / The Priest

Rob Daly
Paul

John Doman
Dr. Baron

Billy Porter
Randy

Carmen Ejogo
Dr. Batiste

Donna Hanover
Debbie Carmichael

Merwin Mondesir
Glenn

Una Kay
Helen

Sonia Benezra
Aunt Sonya

Marcia Bennett
Nurse Stein

Howard Rosenstein
ER Doctor

Jane Wheeler
Karen

David Julian Hirsh
Barton

Arthur Holden
Piano Player

Maurizio Terrazzano
Tom

Rachelle Lefevre
Holly

Erika Rosenbaum
Merry

Victoria Sanchez
Young Mother

Scott Faulconbridge
Man in Front Row

Budd Mishkin
NY1 Reporter

Carmen Echeverria
Young Girl

Gianpaolo Venuta
Young Guy

Nicholas Haze
Waiter

Ruth Chiang
Nurse Woo

Jennifer Seguin
Young Woman

Lindsay Owen Pierre
Friend

David Schaap
Man with Head Injury

Lynne Adams
Head ER Nurse

Kathleen Mackey
Heather

Gabriella Palminteri
Girl in Red Coat

Isabelle Champeau
Party Guest (uncredited)

Lucinda Davis
Nurse Gomez (uncredited)

Francesco Giannini
Family member (uncredited)

Dante Palminteri
Boy in Hospital (uncredited)

Adrianne Richards
Nurse Kline (uncredited)