Jenifer Lewis
Jackie Washington

Tim Curry
Edward Whatsett St. John

T.V. Blake
Antandra Washington (Jackie's Daughter)

Tangie Ambrose
Shaniqua Summers Wells (Jackie's Daughter)

Whoopi Goldberg
Nurse Ethyl Washington Rue Owens (Jackie's Sister)

Robert Bailey Jr.
Wilson Wells (Jackie's Grandson)

Tom Arnold
Marvin Pritz (Jackie's Former Manager)

Loretta Devine
Snookie Tate (Jackie's Childhood Friend)

Julie Hagerty
Pammy Dunbar (Infomercial Host)

David Hyde Pierce
Perry (The Deaf Rehearsal Pianist)

Kathy Najimy
Lola Molina (Jackie's Stalker)

Isabel Sanford
Miss Krumes (Jackie's Play Mama)

JoBeth Williams
Jo Face (Jackie's Vocal Coach)

Mary Wilson
Vesta Crotchley (Jackie's Third Grade Teacher)

Reynaldo Rey
Cadillac Johnson (Retired Pimp)

Loren Freeman
Kim (Jackie's Costume Designer)

Richard Lawson
Milkman Summers (Jackie's Ex-Husband #1)

Patti Austin
Patti Austin (Gospel Singer at Peaches' Funeral)

Kyla Pratt
Little Jackie Washington

Alan Blumenfeld
Ivan (Theatre Manager)

Charles Barkley
Charles Barkley

Diahann Carroll
Diahann Carroll

Eddie Cibrian
Eddie Cibrian

Jackie Collins
Jackie Collins

Don Cornelius
Don Cornelius

Taylor Dayne
Taylor Dayne

Melissa Etheridge
Melissa Etheridge

Kathy Griffin
Kathy Griffin

Sean Hayes
Sean Hayes

Ricki Lake
Ricki Lake

Howie Mandel
Howie Mandel

Camryn Manheim
Camryn Manheim

Penny Marshall
Penny Marshall

Bette Midler
Bette Midler

Liza Minnelli
Liza Minnelli

Rosie O'Donnell
Rosie O'Donnell

Dolly Parton
Dolly Parton

Donna Pescow
Donna Pescow

Chris Rock
Chris Rock

Eva Marie Saint
Eva Marie Saint

Grace Slick
Grace Slick

Robert Townsend
Robert Townsend

Bruce Vilanch
Bruce Vilanch

Dee Freeman
Tired Woman

Jason Kravits
Wimpy Bald Man

Rudy Ray Moore
Bad Guy in Coco Movie

Lance Taylor
Hostage

Sophia Santi
Anti-Fur Protester #1

Scot Zeller
Love Goddess Dancer #1

Paul Terrell Clayton
Musician #1

Ski Carr
Bass Player

Rae Ritke
Reporter #1

Tony Brubaker
Fight Biker

Danny Epper
Fight Biker

Manny Perry
Fight Biker

Scott L. Schwartz
Fight Biker