Dwayne Johnson
Frank Wolff

Emily Blunt
Dr. Lily Houghton

Edgar Ramírez
Lope de Aguirre

Jack Whitehall
McGregor Houghton

Jesse Plemons
Prince Joachim

Paul Giamatti
Nilo

Veronica Falcón
Trader Sam

Dani Rovira
Sancho

Quim Gutiérrez
Melchor

Andy Nyman
Sir James Hobbs-Coddington

Raphael Alejandro
Zaqueu

Simone Lockhart
Anna

Pedro Lopez
Chief

Sulem Calderon
Quila

Mark Ashworth
Society Member 1

Allan Poppleton
Society Worker

James Quattrochi
Italian Tourist

Stephen Dunlevy
Middlepart

Romualdo Castillo
Animal Vendor

Michael H. Cole
Bus Conductor

Hector Banos
Puka Michuna Warrior

Peter Luis Zimmerman
Puka Michuna Warrior

Travis Gomez
Puka Michuna Warrior

David Lengel
Boat Tourist

Justin Randell Brooke
Boat Tourist

Keith Arthur Bolden
Boat Tourist

Marcus Young
Goon (uncredited)

Tanya Wheelock
Boat Tourist (uncredited)

Robert Tinsley
London Guard (uncredited)