Lupita Nyong'o
Adelaide Wilson / Red

Winston Duke
Gabe Wilson / Abraham

Elisabeth Moss
Kitty Tyler / Dahlia

Tim Heidecker
Josh Tyler / Tex

Shahadi Wright Joseph
Zora Wilson / Umbrae

Evan Alex
Jason Wilson / Pluto

Yahya Abdul-Mateen II
Russell Thomas / Weyland

Anna Diop
Rayne Thomas / Eartha

Cali Sheldon
Becca Tyler / Io

Noelle Sheldon
Lindsey Tyler / Nix

Madison Curry
Young Adelaide Wilson / Young Red

Napiera Groves
Dr. Foster

Duke Nicholson
Danny / Tony

Dustin Ybarra
Troy / Brand

Kara Hayward
Nancy / Syd

Jordan Peele
Dying Rabbit / Fun House Narrator (voice) (uncredited)

Darrel Cherney
News Anchor (uncredited)

Alessandro Garcia
EMT (uncredited)

John Higgins
Carny