Jeff Bridges
Roy Pulsipher

Ryan Reynolds
Nick Walker

Kevin Bacon
Bobby Hayes

Mary-Louise Parker
Proctor

Stephanie Szostak
Julia

Robert Knepper
Nawlicki

James Hong
Nick's Avatar / Jerry Chen

Marisa Miller
Roy's Avatar

Mike O'Malley
Elliot

Devin Ratray
Pulaski

Larry Joe Campbell
Murphy

Michael Coons
Detective in Locker Room

Chris Everett
R.I.P.D. Evidence Clerk

Michael Tow
R.I.P.D. Evidence Clerk

Lonnie Farmer
Proctor's Avatar

Piper Mackenzie Harris
Nick's New Avatar

Bill Mootos
Executive

David J. Curtis
Multi-Armed Deado

Kachina Dechert
Goth Chick

Georgia Lyman
Female Cop

Matt McColm
Male Cop

Catherine Kresge
Female TV Reporter

John Burke
Newscaster in Helicopter

Joe Stapleton
R.I.P.D. '70s Cop

Naheem Garcia
R.I.P.D. Cop

Tobias Segal
Clement Smokewagon Perkins

Mike Judge
Various Deado Voices (voice)

Toby Huss
Various Deado Voices (voice)

Jon Olson
Various Deado Voices (voice)

Alexandra Creteau
Red Sox Fan (uncredited)

Jim Ford
Cop #7 (uncredited)

John Franchi
Pedestrian (uncredited)

D.J. 'Shangela' Pierce
Drag Queen Avatar (uncredited)