Johnny Depp
Ed Wood

Martin Landau
Bela Lugosi

Sarah Jessica Parker
Dolores Fuller

Patricia Arquette
Kathy O'Hara

Jeffrey Jones
Criswell

G. D. Spradlin
Reverend Lemon

Vincent D'Onofrio
Orson Welles

Bill Murray
Bunny Breckinridge

Mike Starr
Georgie Weiss

Max Casella
Paul Marco

Brent Hinkley
Conrad Brooks

Lisa Marie
Vampira

Jim Myers
Tor Johnson

Juliet Landau
Loretta King

Clive Rosengren
Ed Reynolds

Norman Alden
Cameraman Bill

Leonard Termo
Makeup Man Harry

Ned Bellamy
Dr. Tom Mason

Danny Dayton
Soundman

Ross Manarchy
Camera Assistant

Bill Cusack
Tony McCoy

Biff Yeager
Rude Boss

Joseph R. Gannascoli
Security Guard

Carmen Filpi
Old Crusty Man

Lisa Malkiewicz
Secretary #1

Melora Walters
Secretary #2

Conrad Brooks
Bartender

Don Amendolia
Salesman

Tommy Bertelsen
Tough Boy

Reid Cruickshanks
Stage Guard

Stanley DeSantis
Mr. Feldman

Lionel Decker
Executive #1

Edmund L. Shaff
Executive #2

Gene LeBell
Ring Announcer

Bobby Slayton
TV Show Host

John Rice
Conservative Man

Catherine Butterfield
Conservative Wife

Mary Portser
Backer's Wife

King Cotton
Hick Backer

Don Hood
Southern Backer

Matthew Barry
Valet

Ralph Monaco
Waiter

Anthony Russell
Busboy

Tommy Bush
Stage Manager

Gregory Walcott
Potential Backer

Charles C. Stevenson Jr.
Another Backer

Rance Howard
Old Man McCoy

Vasek Simek
Professor Strowski

Korla Pandit
Indian Musician

Patti Tippo
Nurse

Ray Baker
Doctor

Louis Lombardi
Rental House Manager

Jim Boyce
Theatre Manager

Ben Ryan Ganger
Angry Kid

Ryan Holihan
Frantic Usher

Charlie Holliday
Tourist

Adam Drescher
Photographer #1

Daniel Riordan
Pilot / Strapping Young Man

Mickey Cottrell
Hammy Alien

Maurice LaMarche
Orson Welles (voice) (uncredited)

Jesse Hernandez
Wrestling Opponent

Lena Banks
Sexy Pedestrian (uncredited)

Ada Tai
Vampira's Friend (uncredited)

Arlene Tai
Vampira's Friend (uncredited)

Rayder Woods
Car Vandal (uncredited)

Bill Blair
Carny (uncredited)

Eugenie Bondurant
Dagmar (uncredited)

Mike Breyer
Photographer (uncredited)

Patrick Cranshaw
Editor on Studio Lot (uncredited)

Johnny Meyer
Kid At Movie Theater (uncredited)