Tobey Maguire
Spider-Man / Peter Parker

Kirsten Dunst
Mary Jane Watson

James Franco
New Goblin / Harry Osborn

Thomas Haden Church
Sandman / Flint Marko

Topher Grace
Venom / Eddie Brock

Bryce Dallas Howard
Gwen Stacy

Rosemary Harris
May Parker

J.K. Simmons
J. Jonah Jameson

James Cromwell
Captain Stacy

Dylan Baker
Dr. Curt Connors

Theresa Russell
Emma Marko

Bill Nunn
Joseph 'Robbie' Robertson

Bruce Campbell
Maître D'

Elizabeth Banks
Miss Brant

Ted Raimi
Hoffman

Perla Haney-Jardine
Penny Marko

Willem Dafoe
Green Goblin / Norman Osborn

Cliff Robertson
Ben Parker

Ilya Baskin
Mr. Ditkovitch

Mageina Tovah
Ursula

John Paxton
Houseman

Becky Ann Baker
Mrs. Stacy

Stan Lee
Man in Times Square

Michael Papajohn
Dennis Carradine / Carjacker

Joe Manganiello
Flash Thompson

Lucy Gordon
Jennifer Dugan

Steve Valentine
Photographer

Tim Maculan
Play Director

Marc Vann
Play Producer

Joe Bays
Jazz Club Manager

Gregg Daniel
Precinct Detective

Rogelio T. Ramos
Emergency Room Doctor

Timothy Patrick Quill
Crane Operator

Kathryn Bryding
Woman Outside Theater

Joe Virzi
Police Detective

Bill E. Rogers
New Jersey State Policeman

April Parker Jones
Test Site Technician

Edward Padilla
Test Site Technician

Robert Curtis Brown
Test Site Technician

Paul Terrell Clayton
Test Site Technician

Carolyn Neff
Test Site Technician

Christina Cindrich
Test Site Technician

Sonya Maddox
ICU Nurse

Andre B. Blake
Crane Disaster Radio Policeman

Emilio Rivera
Policeman at Sand Truck

Reynaldo Gallegos
Armored Car Driver

Jim Coope
Newstand Patron

Dean Edwards
Newsstand Patron

Margaret Laney
Newsstand Patron

Toni Wynne
Congratulatory Woman at Daily Bugle

Tanya Bond
Jazz Club Waitress

Mark Kubr
Jazz Club Bouncer

Emma Raimi
Girl With Camera

Dan Callahan
Jazz Club Musician

Ron King
Jazz Club Musician

Frank Anello
NYPD Officer (uncredited)

Anya Avaeva
Model (uncredited)

David Backus
Bucket Boy (uncredited)

John Crann
Theater Patron (uncredited)

Amy V. Dewhurst
Columbia Grad Student (uncredited)

Logan Fry
Automobile Driver (uncredited)

Andrew James Jones
Jazz Club Bouncer (uncredited)

Natalie Jones
Girl at Key Ceremony (uncredited)

Bernadette Lords
British Publicist (uncredited)

Natalie McNeil
Girl Screaming in Camaro (uncredited)

Martha Millan
Oscorp Receptionist (uncredited)

Claudia Katz Minnick
Robbie's Assistant (uncredited)

Jen Oda
Beautiful Girl (uncredited)

Anjelia Pelay
Beautiful Woman (uncredited)

Vanessa Reseland
Beautiful Woman (uncredited)

La Rivers
Beautiful Woman (uncredited)

Bria Roberts
Businesswoman (uncredited)

Vanessa Ross
Sandman Victim (uncredited)

Shade Rupe
City Hall Cheerer (uncredited)

Jennifer Sparks
Jazz Club Waitress (uncredited)

Christopher Stadulis
NY Firefighter (uncredited)

Evelyn Vaccaro
Beautiful Woman (uncredited)

Jennifer Weston
ER Nurse (uncredited)

Craig 'Radio Man' Castaldo
Radioman (uncredited)