Ryan Reynolds
Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin
Cable

Morena Baccarin
Vanessa

Julian Dennison
Firefist

Zazie Beetz
Domino

T.J. Miller
Weasel

Leslie Uggams
Blind Al

Karan Soni
Dopinder

Brianna Hildebrand
Negasonic Teenage Warhead

Jack Kesy
Black Tom

Eddie Marsan
Headmaster

Shioli Kutsuna
Yukio

Stefan Kapičić
Colossus (voice)

Randal Reeder
Buck

Nikolai Witschl
Head Orderly Frye

Thayr Harris
Sergei Valishnikov

Rob Delaney
Peter

Lewis Tan
Shatterstar

Bill Skarsgård
Zeitgeist

Terry Crews
Bedlam

Brad Pitt
Vanisher

Paul Wu
Hong Kong Boss

Robert Maillet
Sluggo

Alan Tudyk
Luke - Redneck #1

Matt Damon
Redneck #2

Michasha Armstrong
Swat Captain (School)

Joe Doserro
Bus Driver

Hayley Sales
Cable's Wife

Islie Hirvonen
Cable's Daughter

Jagua Arneja
Tree Trimmer #1

Gerry South
Tree Trimmer #2

Mike Dopud
Prison Guard

Luke Roessler
Cereal Kid

Andy Canete
Neighbor #1

Tanis Dolman
Neighbor #2

Hunter Dillon
Branding Boy

Sala Baker
Older Firefist

Sonia Sunger
News Reporter (Irene)

Paul Wernick
News Cameraman

Rhett Reese
News Helicopter Pilot

Abiola Uthman
Chinook Pilot

Tony Bailey
Black Tom Gang Member

Alex Kliner
Park Bench Couple

David Leitch
Ground Chuck Mutant

Valencia Budijanto
Zoo Kid

Stefania Indelicato
Bystander

Paul Lazenby
Strip Club Baddie

Noah Beggs
Strip Club Baddie

Andrei Kovski
Strip Club Baddie

Alicia Morton
Vocalist on 'Tomorrow' (voice)

Fred Savage
Fred Savage (uncredited)

Andre Tricoteux
On-Set Colossus (uncredited)

James McAvoy
Charles Xavier / Professor X (uncredited)

Nicholas Hoult
Hank McCoy / Beast (uncredited)

Evan Peters
Peter Maximoff / Quicksilver (uncredited)

Tye Sheridan
Scott Summers / Cyclops (uncredited)

Alexandra Shipp
Ororo Monroe / Storm (uncredited)

Kodi Smit-McPhee
Kurt Wagner / Nightcrawler (uncredited)