Karen Gillan
Sam

Lena Headey
Scarlet

Chloe Coleman
Emily

Carla Gugino
Madeleine

Michelle Yeoh
Florence

Angela Bassett
Anna May

Paul Giamatti
Nathan

Ralph Ineson
Jim McAlester

Adam Nagaitis
Virgil

Michael Smiley
Dr. Ricky

Joanna Bobin
Rose

Freya Allan
Young Sam

Ed Birch
Lead Russian Thug

David Zimmerschied
Factory Goon

Samuel Anderson
David

Mai Duong Kieu
Nurse

Jack Bandeira
Crow

David Burnell IV
Shocker

Ivan Kaye
Yankee

Anita Olatunji
Nathan's Assistant

Matthias Dittmer
Firm Oldest Vulture

Joshua Grothe
Dracula

Lee Huang
Wolfman

Jonathan Failla
Nathan's Fancy House Thug

Mike Möller
Thug (uncredited)