Steve McQueen
Henri "Papillon" Charriere

Dustin Hoffman
Louis Dega

Victor Jory
Indian Chief

Don Gordon
Julot

Anthony Zerbe
Toussaint

Robert Deman
Maturette

Woodrow Parfrey
Clusiot

Bill Mumy
Lariot

George Coulouris
Dr. Chatal

Ratna Assan
Zoraima

William Smithers
Warden Barrot

Val Avery
Pascal

Gregory Sierra
Antonio

Vic Tayback
Sergeant

Mills Watson
Guard

Ron Soble
Santini

Barbara Morrison
Mother Superior

Don Hanmer
Butterfly Trader

E.J. André
Old Con

Richard Angarola
Commandant

Jack Denbo
Classification Officer

Len Lesser
Guard

John Quade
Masked Breton

Fred Sadoff
Deputy Warden

Allen Jaffe
Turnkey

Liam Dunn
Old Trustee

Anne Byrne Hoffman
Mrs. Dega (uncredited)

Dalton Trumbo
Commandant (uncredited)

Richard Farnsworth
Manhunter (uncredited)

Peter Brocco
Doctor (uncredited)