Benedict Cumberbatch
Louis Wain

Claire Foy
Emily Wain

Andrea Riseborough
Caroline Wain

Toby Jones
Sir William Ingram

Sharon Rooney
Josephine Wain

Aimee Lou Wood
Claire Wain

Hayley Squires
Marie Wain

Stacy Martin
Felicie Wain

Phoebe Nicholls
Mrs Wain

Adeel Akhtar
Dan Rider

Asim Chaudhry
Herbert Railton

Taika Waititi
Max Kase

Crystal Clarke
Alicia Simmonds

Daniel Rigby
Bendigo

Richard Ayoade
Henry Wood

Julian Barratt
Dr Elphick

Dorothy Atkinson
Mrs Du Frayne

Nick Cave
H.G. Wells

Olivia Colman
Narrator

Fehinti Balogun
Praga

Jamie Demetriou
Woodville Jr.

Sophia Di Martino
Judith

Siobhán McSweeney
Dr Cooke

Stewart Scudamore
Dr Quantock

Simon Munnery
Jem Mace

James Eeles
Train Attendant

Olivier Richters
Journeyman Boxer

Indica Watson
Young Felicie Wain

Dorothy Atkinson
Mrs. DuFrayne

Kiki May
Paper Girl (1891)