Hilary Swank
Claire Morgan

Robert De Niro
Stan Harris

Michelle Pfeiffer
Ingrid Withers

Josh Duhamel
Sam

Sarah Jessica Parker
Kim Doyle

Zac Efron
Paul

Lea Michele
Elise

Ashton Kutcher
Randy

Halle Berry
Nurse Aimee

Jon Bon Jovi
Daniel Jensen

Katherine Heigl
Laura Carrington

Seth Meyers
Griffin Byrne

Jessica Biel
Tess Byrne

Til Schweiger
James Schwab

Carla Gugino
Spiritual Dr. Morriset

Cary Elwes
Stan's Doctor

Sofía Vergara
Ava

Héctor Elizondo
Kominsky

Abigail Breslin
Hailey Doyle

Ludacris
Brendan

Sarah Paulson
Grace Schwab

Alyssa Milano
Nurse Mindy

Jake T. Austin
Seth

Katherine McNamara
Lily Bowman

Nat Wolff
Walter

Yeardley Smith
Maude

Ryan Seacrest
Self

Michael Bloomberg
Self

Fiona Choi
Balinese Woman - Resolution Tour

Jim Belushi
Building Super

Mara Davi
Mika

Cassidy Reiff
Piper

Russell Peters
Chef Sunil

Serena Poon
Chef Ming

Common
Soldier

Jackie Seiden
Bride Trish

Joey McIntyre
Groom Rory

Beth Kennedy
Piper's Mom

Larry Miller
Harley (segment "Ahern Party")

Christine Lakin
Waitress Alyssa

Shea Curry
Wendy

Sandra Taylor
Patty

Matthew Broderick
Mr. Buellerton (uncredited)

John Lithgow
Jonathan Cox (uncredited)

Juliette Angelo
Sadie

Mary Marguerite Keane
Pet Adoption Clerk

Barbara Marshall
Head Nurse Helen

Penny Marshall
Penny Marshall

Cherry Jones
Mrs Rose Ahern

Charlotte Marshall-Fricker
Caring Teenage Girl (segment "Resolution Tour")

Michael Mandell
Murray (segment "Resolution Tour")