Katherine Heigl
Jane Nichols

James Marsden
Kevin Doyle

Malin Åkerman
Tess Nichols

Judy Greer
Casey

Edward Burns
George

Melora Hardin
Maureen

Brian Kerwin
Hal Nichols

Maulik Pancholy
Trent

David Castro
Pedro

Krysten Ritter
Gina the Goth

Michael Paul
Taxi Fahrer Khaleel

Jennifer Lim
Bridal Salesgirl

Danielle Skraastad
Bride Suzanne

Yetta Gottesman
Hip Bridesmaid

Erin Fogel
Shari Rabinowitz

Bern Cohen
Rabbi

Peyton List
Young Jane

Jane Pfitsch
Cousin Lisa

Ronald Guttman
Antoine

Ron Simons
Boathouse Chef

Robert Clohessy
Dive Bartender

Michael Mosley
Bar Dude

Alyssa Bresnahan
Diner Waitress

Jennifer Bassey
Jane's Aunt

Alexa Havins
Boat Bride

Kathryn Weisbeck
Tara Bride (uncredited)