Chris Hemsworth
Orion Pax / Optimus Prime (voice)

Brian Tyree Henry
D-16 / Megatron (voice)

Scarlett Johansson
Elita-1 (voice)

Keegan-Michael Key
B-127 (voice)

Jon Hamm
Sentinel Prime (voice)

Steve Buscemi
Starscream (voice)

Laurence Fishburne
Alpha Trion (voice)

Vanessa Liguori
Airachnid (voice)

Jon Bailey
Soundwave (voice)

Jason Konopisos-Alvarez
Shockwave / Guard 2 (voice)

Evan Michael Lee
Jazz (voice)

James Remar
Zeta Prime (voice)

Isaac C. Singleton, Jr.
Darkwing (voice)

Steve Blum
Announcer Bot / Guard 1 (voice)

Jinny Chung
Chromia / Arcee (voice)

Josh Cooley
Control Room Guys / PA System / Skywarp (voice)