Ben Stiller
Alex Rose

Drew Barrymore
Nancy Kendricks

Eileen Essell
Mrs. Connelly

Harvey Fierstein
Kenneth

Justin Theroux
Coop

James Remar
Chick

Robert Wisdom
Officer Dan

Swoosie Kurtz
Jean

Wallace Shawn
Herman

Maya Rudolph
Tara

Amber Valletta
Celine

Cheryl Bartel
Ginger

Tim Maculan
Terrence

Jackie Sandler
Bartender

Evgeniy Lazarev
Mr. Dzerzhinsky

Kumar Pallana
Indian Restaurant Owner

Michelle Krusiec
Dr. Kang

Linda Porter
Old Biddy

Edward Edwards
Antique Dealer

Louis Giambalvo
Pharmacist

Tracey Walter
Pharmacy Customer

John Hamburg
Mr. Friedman

Christina Kirk
Mrs. Friedman

Jenette Goldstein
Moderator

Christopher Doyle
Tavern Bartender

Geraldine Hughes
Receptionist

Danny DeVito
Narrator (voice) (uncredited)

Larry Vigus
Man on Street (uncredited)