Patricia Clarkson
Mia

Rosario Dawson
Lili

Lyndsy Fonseca
Cheyanne

Ginnifer Goodwin
Charlotte

Jeanne Tripplehorn
Pearl

Emily Skinner
Sally

Carla Gallo
Laura

Aisha Hinds
Bernice

Josh Holloway
Bill

Jennifer Morrison
Sheila

Austin Nichols
Edward

Annie Potts
Helen

Xander Berkeley
Peter

Kathy Najimy
Rocky

Romy Rosemont
Lynne

Tony Shalhoub
Mitch

Jenifer Lewis
Maggie

Tracee Ellis Ross
Alyssa

Jeffrey Tambor
Danny

David Eigenberg
Lenny

Taylor Kinney
Tommy

Bob Newhart
Dr. Roth

Ravi Patel
Dr. Desai

Alan Ruck
Sam Jarente

Scott Wilson
Bill (Older)

Kirk Baily
Scott

Ava Acres
Pearl at age 7

Josh Dallas
Henry