Joaquin Phoenix
Beau Wassermann

Patti LuPone
Mona Wassermann

Amy Ryan
Grace

Nathan Lane
Roger

Kylie Rogers
Toni

Denis Ménochet
Jeeves

Parker Posey
Elaine Bray

Zoe Lister-Jones
Young Mona

Armen Nahapetian
Teen Beau

Julia Antonelli
Teen Elaine

Stephen McKinley Henderson
Therapist

Richard Kind
Dr. Cohen

Hayley Squires
Penelope

Julian Richings
Strange Man

Bill Hader
UPS Guy

Alicia Rosario
Liz

Catherine Bérubé
Hero Beau's Wife

Stephanie Herrera
Martha

Bradley Fisher
Birthday Boy Stab Man

Michael Esper
Officer Johnson

Manuel Tadros
Cheapo Depot Cashier

Karl Roy
Man with Face Tattoos

Tyrone Benskin
Rattled Businessman

Archie Madekwe
Laughing Man

Luis Oliva
Crust Punk (Eyes Gouged)

Marie-Michelle Garon
Fraught Mother Looking for Boat Boy

Maev Beaty
Angel / Play Narrator

Patrick Kwok-Choon
Orphan Hero

Michael Gandolfini
Beau’s Son

Théodore Pellerin
Beau’s Son

Mike Taylor
Beau’s Son

Ryan S. Hill
Hero Beau's Young Son

Bentley Hughes
Hero Beau's Young Son

Kwasi Songui
Orphan Ladybug Man

Sylvain Landry
Orphan Man w/Mandolin

Tristan D. Lalla
Costume Designer Orphan

Emmanuel Schwartz
Orphan Chorus Member

Cat Lemieux
Orphan Chorus Member

Lily Bird
Samanda

Arthur Holden
Duncan / God on Cloud / Hero Beau’s Wife

Alex Bisping
Orphan Production Designer

Joe Cobden
News Correspondent (Brian Galloway)

Harry Standjofski
Superintendent / Catering Manager

Anana Rydvald
Teen Elaine's Mother

Isabelle Brabant
Nurse

David Mamet
Rabbi

Karim Babin
Caterer

Lee Villeneuve
Mona Henchman Who Throws Lawyer

Marc-André Casavant
Dancer (uncredited)

Ari Aster
A Neighbor of Beau's (uncredited)